{"id":5579,"date":"2021-04-27T22:15:47","date_gmt":"2021-04-27T19:15:47","guid":{"rendered":"https:\/\/temacons.com\/pharmatech-case-study-caleva-study-on-the-importance-of-granulation\/"},"modified":"2023-07-31T15:53:05","modified_gmt":"2023-07-31T12:53:05","slug":"pharmatech-case-study-caleva-study-on-the-importance-of-granulation","status":"publish","type":"post","link":"https:\/\/temacons.com\/en\/pharmatech-case-study-caleva-study-on-the-importance-of-granulation\/","title":{"rendered":"Caleva Case Study &#8211; Caleva Study on the Importance of Granulation"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5579\" class=\"elementor elementor-5579\" data-elementor-settings=\"{&quot;element_pack_global_tooltip_width&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_width_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_width_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_padding&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_padding_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_padding_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true}}\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6e9cfc8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6e9cfc8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-03625a8\" data-id=\"03625a8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9a0edde elementor-widget elementor-widget-text-editor\" data-id=\"9a0edde\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Our customer, a major pharmaceutical, biotech &amp; nutraceutical manufacturer with an extensive portfolio of products. For reasons of confidentiality we do not name them.<\/p><p>One of our Production Extruder &amp; Spheronizer Systems for manufacturing on a large-scale was used in trials by the manufacturer, but the pellets produced were not acceptable. As the product was already registered, the composition could not be changed. The only changes permitted were to vary:<\/p><ul><li>The amount of binder addition<\/li><li>The operational parameters of the manufacturing process<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-20937df elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"20937df\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-41b67f3\" data-id=\"41b67f3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ac71bad elementor-widget elementor-widget-image\" data-id=\"ac71bad\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/temacons.com\/wp-content\/uploads\/elementor\/thumbs\/Caleva-case-study-Multi-Lab-training-in-variable-density-extrusion-in-the-Caleva-training-laboratory-pdf-q65m80gnnmu1nghp669i8c7hjxm6qpd4yl98cxhzpc.jpg\" title=\"Caleva-case-study&#8211;Multi-Lab-training-in-variable-density-extrusion-in-the-Caleva-training-laboratory-pdf\" alt=\"Caleva-case-study--Multi-Lab-training-in-variable-density-extrusion-in-the-Caleva-training-laboratory-pdf\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-7d4aac3\" data-id=\"7d4aac3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f99e3bf elementor-widget elementor-widget-bdt-call-out\" data-id=\"f99e3bf\" data-element_type=\"widget\" data-widget_type=\"bdt-call-out.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"bdt-ep-callout bdt-ep-callout-button-align-right bdt-grid bdt-grid-large bdt-flex-middle\">\n\t\t\t<div class=\"bdt-width-expand bdt-first-column\">\n\t\t\t\t\t\t\t\t\t<h3\t\t\t\t\t\tclass=\"bdt-ep-callout-title\">\n\t\t\t\t\t\tDownload PDF\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"bdt-ep-callout-description\">\n\t\t\t\t\t\tDownload a pdf version of this case study to read or print later\n\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t<div class=\"bdt-ep-callout-button-wrap bdt-width-auto@m\">\n\t\t\t\t<a href=\"https:\/\/cdn2.hubspot.net\/hubfs\/4021250\/Caleva-spheronization-challenge-granulation-case-study.pdf\" class=\"bdt-ep-callout-button\" target=\"_blank\" rel=\"noopener\">\n\n\t\t\t\t\t<span >\n\n\t\t\t\t\t\tClick Here\n\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\n\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-586f266 elementor-widget elementor-widget-text-editor\" data-id=\"586f266\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Two key conditions were observed at the customer site<\/h3><p>\u00a0<\/p><ul><li>There was no way to measure the\u00a0<strong>consistency<\/strong>\u00a0of the material during or after granulation<\/li><li>The granulation did not appear to be very homogeneous<br \/><br \/>In our experience, at the development stage, the granulation parameters are often underestimated and the importance and the influence of this process on the final product outcome is often overlooked.<br \/><br \/><hr \/><h5>Our investigation examines this idea and a \u201croad map\u201d was created which allowed the customer to move forward to manufacture an acceptable product\u00a0<\/h5><hr \/><\/li><\/ul><p><br \/><br \/><\/p><h4>General Conclusions &#8211; the granulation parameters clearly require adjustment<\/h4><p>\u00a0<\/p><ul><li>A more aggressive granulation gives a formulation that is easier to manage and can produce good pellets on a lab scale using the Caleva Multi Lab<\/li><li>None of the three processes (Granulation, Extrusion and Spheronization) show any difficulty<\/li><li>There is no evidence of the problematic stickiness<\/li><li>The process time is longer than we would ideally want it to be<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9b929d elementor-icon-list--layout-inline elementor-align-center elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"e9b929d\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items elementor-inline-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-inline-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.caleva.com\/knowledge-base\/caleva-study-on-the-importance-of-granulation\" target=\"_blank\" rel=\"noopener\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-external-link-square-alt\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M448 80v352c0 26.51-21.49 48-48 48H48c-26.51 0-48-21.49-48-48V80c0-26.51 21.49-48 48-48h352c26.51 0 48 21.49 48 48zm-88 16H248.029c-21.313 0-32.08 25.861-16.971 40.971l31.984 31.987L67.515 364.485c-4.686 4.686-4.686 12.284 0 16.971l31.029 31.029c4.687 4.686 12.285 4.686 16.971 0l195.526-195.526 31.988 31.991C358.058 263.977 384 253.425 384 231.979V120c0-13.255-10.745-24-24-24z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Kaynak<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Our customer, a major pharmaceutical, biotech &#038; nutraceutical manufacturer with an extensive portfolio of products. For reasons of confidentiality we do not name them.<\/p>\n","protected":false},"author":2,"featured_media":4408,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[62],"tags":[],"class_list":["post-5579","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-library"],"_links":{"self":[{"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/posts\/5579","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/comments?post=5579"}],"version-history":[{"count":0,"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/posts\/5579\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/media\/4408"}],"wp:attachment":[{"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/media?parent=5579"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/categories?post=5579"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/tags?post=5579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}