{"id":7519,"date":"2024-02-29T14:11:17","date_gmt":"2024-02-29T11:11:17","guid":{"rendered":"https:\/\/temacons.com\/?p=7519"},"modified":"2024-02-29T14:17:09","modified_gmt":"2024-02-29T11:17:09","slug":"a-solution-that-can-save-lives","status":"publish","type":"post","link":"https:\/\/temacons.com\/en\/a-solution-that-can-save-lives\/","title":{"rendered":"A solution that can save lives"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"7519\" class=\"elementor elementor-7519\" data-elementor-settings=\"{&quot;element_pack_global_tooltip_width&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_width_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_width_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;element_pack_global_tooltip_padding&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_padding_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_padding_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true},&quot;element_pack_global_tooltip_border_radius_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;top&quot;:&quot;&quot;,&quot;right&quot;:&quot;&quot;,&quot;bottom&quot;:&quot;&quot;,&quot;left&quot;:&quot;&quot;,&quot;isLinked&quot;:true}}\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d685d3f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d685d3f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f512a0a\" data-id=\"f512a0a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c3bf639 elementor-icon-list--layout-inline elementor-align-center elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"c3bf639\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items elementor-inline-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-inline-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.caleva.com\/knowledge-base\/investigating-the-impact-of-process-variables-in-formulation-development\" target=\"_blank\" rel=\"noopener\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-external-link-square-alt\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M448 80v352c0 26.51-21.49 48-48 48H48c-26.51 0-48-21.49-48-48V80c0-26.51 21.49-48 48-48h352c26.51 0 48 21.49 48 48zm-88 16H248.029c-21.313 0-32.08 25.861-16.971 40.971l31.984 31.987L67.515 364.485c-4.686 4.686-4.686 12.284 0 16.971l31.029 31.029c4.687 4.686 12.285 4.686 16.971 0l195.526-195.526 31.988 31.991C358.058 263.977 384 253.425 384 231.979V120c0-13.255-10.745-24-24-24z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Source<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0c31438 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0c31438\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a7dbd79\" data-id=\"a7dbd79\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9a39886 elementor-widget elementor-widget-text-editor\" data-id=\"9a39886\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Therapy with injectables (such as cytostatics, hormone preparations, neurological drugs, other special injectables) promises patients significantly improved chances of recovery. Doctors inject the active ingredient as a sterile liquid solution. Systems from Waldner play an important role in its production.<\/p><p><strong>About half a million people in Germany are diagnosed with cancer every year. Due to improved medical care, however, the chances of being cured have increased significantly in recent years. Chemotherapy plays an essential role in the treatment. This involves the hospital staff intravenously administering an active substance known as a cytostatic. EVER Pharma, with headquarters in Unterach, Austria, has specialised in the production of this active ingredient, along with other classes of active ingredients.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3d4afa0 elementor-widget elementor-widget-image\" data-id=\"3d4afa0\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/temacons.com\/wp-content\/uploads\/2024\/02\/Blog_Waldner_Ever-Pharma_Solution-that-saves-lives.webp\" class=\"attachment-full size-full wp-image-7512\" alt=\"\" srcset=\"https:\/\/temacons.com\/wp-content\/uploads\/2024\/02\/Blog_Waldner_Ever-Pharma_Solution-that-saves-lives.webp 1024w, https:\/\/temacons.com\/wp-content\/uploads\/2024\/02\/Blog_Waldner_Ever-Pharma_Solution-that-saves-lives-300x200.webp 300w, https:\/\/temacons.com\/wp-content\/uploads\/2024\/02\/Blog_Waldner_Ever-Pharma_Solution-that-saves-lives-768x512.webp 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2f7f391 elementor-widget elementor-widget-text-editor\" data-id=\"2f7f391\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1rem;\">Sterile solutions or suspensions are needed to administer injectables. The basic material is a powder from which EVER Pharma produces a liquid in an absolutely pure and sterile environment at a plant in Jena, in Thuringia. The liquid solution is then filled into vials, ampoules or ready-to-use syringes. The Process Systems Division provides a consistent, perfectly coordinated complete solution for the entire process of liquefaction (formulation). This ranges from the containers to the isolators and from all of the peripherals to the control components. The Process Systems team supplied and installed a total of three plants in Jena: one for the production of neurologically active substances, one for hormone preparations and one for the production of cytostatics.<\/span><\/p><p><strong>Isolators protect employees from toxic atmosphere<\/strong><\/p><p>\u201cThe protection of our employees during the entire manufacturing process is our top priority. Our employees must be able to rely 100% on the technology around them. Isolators offer maximum safety here, states Dr Manfred Nussbaumer, Head of Engineering at EVER Pharma. This is because the operators must not come into contact with or inhale the highly toxic active ingredient powder under any circumstances. You can open the containers at the isolator using gloves, remove the powder and weigh out the correct quantity.\u00a0 The weighed active ingredient is then also transferred in an isolator to a container and then stirred together with the water for injection, dissolved and mixed with additives.<\/p><p>\u201cBasically, two different types of containers are used: The mobile version holds up to 250 litres of dissolving liquid and can be pushed up to the isolator and docked. To prevent contamination of the ambient air, the powder is transferred hermetically into the container. There is also a stationary version that can hold up to 1,000 litres and is firmly connected to the isolator,\u201d explains Thomas Knaup, sales employee at Waldner Process Systems. After the dissolution process, the liquid is fed directly to machines that fill the solution into syringes, ampoules or special injection vials. In addition to the isolators and containers, Process Systems also supplies all the process equipment required for the transfer of the active ingredient and the seamless interaction of the individual components. This also includes piping, valves and technical systems for taking samples from the liquid.<\/p><p><strong>CIP system ensures sterile environment<\/strong><\/p><p>\u201cIt is important for us to ensure an absolutely sterile environment throughout the process. Since we produce and fill various products for our customers, the systems must be comprehensively cleaned at regular intervals. This is the only way to reliably avoid cross-contamination,\u201d says Dr Nussbaumer. \u201cFor this purpose, we have provided a Cleaning-in-Place (CIP) system with which the entire equipment can be flushed and cleaned without time-consuming disassembly,\u201d adds Thomas Knaup. Next comes the sterilisation of the components, most of whose surfaces are made of stainless steel. Here, they are heated to 130 degrees to kill any remaining germs. \u201cFor the entire process chain, from the production of the solution to the cleaning and sterilisation of the equipment, all system components come from a single source. This is enormously important to ensure the highest level of sterility,\u201d says Thomas Knaup.<\/p><p>HAS Technologie GmbH, which has been part of the Waldner Group since 2022, is responsible for the entire control technology, including the process management system. Sophisticated control software including recipe management paves the way for the continuous automation of the systems.<\/p><p><strong>Holistic solution package from a single source<\/strong><\/p><p>\u201cWe benefit from a holistic solution package that allows us to handle all batch formulation processes consistently. Whether containers, isolators, transfer technology or control systems\u00a0\u2013 we receive all the necessary components from a single source. This allows us to reduce technical interfaces to a large extent and thus guarantee the consistency of our production processes,\u201d states Dr Manfred Nussbaumer. \u201cWe already knew the Waldner experts and their professional working methods from an earlier project involving a different company constellation. At that time, a very competent team had emerged with whom we quickly built up trust. Our high level of satisfaction was ultimately the deciding factor that led us to place another order with this proven partner,\u201d adds the project manager at EVER Pharma.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ae0639 elementor-icon-list--layout-inline elementor-align-center elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"8ae0639\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items elementor-inline-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-inline-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.waldner.de\/en\/about-us\/magazine\/a-solution-that-can-save-lives\/\" target=\"_blank\" rel=\"noopener\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-external-link-square-alt\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M448 80v352c0 26.51-21.49 48-48 48H48c-26.51 0-48-21.49-48-48V80c0-26.51 21.49-48 48-48h352c26.51 0 48 21.49 48 48zm-88 16H248.029c-21.313 0-32.08 25.861-16.971 40.971l31.984 31.987L67.515 364.485c-4.686 4.686-4.686 12.284 0 16.971l31.029 31.029c4.687 4.686 12.285 4.686 16.971 0l195.526-195.526 31.988 31.991C358.058 263.977 384 253.425 384 231.979V120c0-13.255-10.745-24-24-24z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Source<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Source Therapy with injectables (such as cytostatics, hormone preparations, neurological drugs, other special injectables) promises patients significantly improved chances of recovery. Doctors inject the active ingredient as a sterile liquid solution. Systems from Waldner play an important role in its production. About half a million people in Germany are diagnosed with cancer every year. Due [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":7512,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[44,62,51],"tags":[37],"class_list":["post-7519","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-en","category-library","category-onfab-en","tag-sektorden-haberler-en"],"_links":{"self":[{"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/posts\/7519","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/comments?post=7519"}],"version-history":[{"count":0,"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/posts\/7519\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/media\/7512"}],"wp:attachment":[{"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/media?parent=7519"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/categories?post=7519"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/temacons.com\/en\/wp-json\/wp\/v2\/tags?post=7519"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}